Keratin 17 modulates the immune topography of pancreatic cancer

Abstract Background The immune microenvironment impacts tumor growth, invasion, metastasis, and patient survival and may provide opportunities for therapeutic intervention in pancreatic ductal adenocarcinoma (PDAC). Although never studied as a potential modulator of the immune response in most cance...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Lyanne Delgado-Coka, Michael Horowitz, Mariana Torrente-Goncalves, Lucia Roa-Peña, Cindy V. Leiton, Mahmudul Hasan, Sruthi Babu, Danielle Fassler, Jaymie Oentoro, Ji-Dong K Bai, Emanuel F. Petricoin, Lynn M. Matrisian, Edik Matthew Blais, Natalia Marchenko, Felicia D. Allard, Wei Jiang, Brent Larson, Andrew Hendifar, Chao Chen, Shahira Abousamra, Dimitris Samaras, Tahsin Kurc, Joel Saltz, Luisa F. Escobar-Hoyos, Kenneth R. Shroyer
Format:	Article
Language:	English
Published:	BMC 2024-05-01
Subjects:	Keratin 17 Pancreatic ductal adenocarcinoma Cancer immunology Cancer biomarker Immune microenvironment Multiplexed immunohistochemistry
Online Access:	https://doi.org/10.1186/s12967-024-05252-1