Structure‐Activity Relationship of NF023 Derivatives Binding to XIAP‐BIR1

Abstract Inhibitors of Apoptosis Proteins (IAPs) are conserved E3‐ligases that ubiquitylate substrates to prevent apoptosis and activate the NF‐kB survival pathway, often deregulated in cancer. IAPs‐mediated regulation of NF‐kB signaling is based on the formation of protein complexes by their type‐I...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:ChemistryOpen
المؤلفون الرئيسيون: Dr. Luca Sorrentino, Dr. Federica Cossu, Dr. Mario Milani, Bilge Malkoc, Dr. Wen‐Chieh Huang, Dr. Shwu‐Chen Tsay, Prof. Jih Ru Hwu, Dr. Eloise Mastrangelo
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Wiley-VCH 2019-04-01
الموضوعات:
apoptosis
drug discovery
structure-activity relationship
in silico docking
protein structures
الوصول للمادة أونلاين:https://doi.org/10.1002/open.201900059

الانترنت

https://doi.org/10.1002/open.201900059

مواد مشابهة