5-FU@HFn combined with decitabine induces pyroptosis and enhances antitumor immunotherapy for chronic myeloid leukemia

Abstract Background Tyrosine kinase inhibitors (TKIs) constitute the primary treatment for chronic myeloid leukemia (CML). However, resistance to TKIs often leads to treatment failure. Pyroptosis, a form of programmed cell death, has emerged as a promising strategy in cancer therapy due to its abili...

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Bibliographic Details

Published in:	Journal of Nanobiotechnology
Main Authors:	Zuowei Yuan, Guoyun Jiang, Ying Yuan, Qian Liang, Yaxin Hou, Wenyao Zhang, Lujia Tang, Kelong Fan, Wenli Feng
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Chronic myeloid leukemia Ferritin nanocage 5-fluorouracil Pyroptosis Antitumor immunity
Online Access:	https://doi.org/10.1186/s12951-025-03335-9