Systematic review and meta-analysis on the therapeutic reference range for escitalopram: Blood concentrations, clinical effects and serotonin transporter occupancy

IntroductionA titration within a certain therapeutic reference range presupposes a relationship between the blood concentration and the therapeutic effect of a drug. However, this has not been systematically investigated for escitalopram. Furthermore, the recommended reference range disagrees with m...

Full description

Bibliographic Details

Published in:	Frontiers in Psychiatry
Main Authors:	Luzie Eichentopf, Christoph Hiemke, Andreas Conca, Jan Engelmann, Manfred Gerlach, Ursula Havemann-Reinecke, Gudrun Hefner, Vincenzo Florio, Maxim Kuzin, Klaus Lieb, Margareta Reis, Thomas G. Riemer, Alessandro Serretti, Georgios Schoretsanitis, Gerald Zernig, Gerhard Gründer, Xenia M. Hart
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	escitalopram reference range blood level therapeutic drug monitoring antidepressant response clinical effects
Online Access:	https://www.frontiersin.org/articles/10.3389/fpsyt.2022.972141/full