Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers

The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing a tacrine residue and a 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) or 1,4-dideoxy-1,4-imino-L-arabinitol (LAB) moiety held together via linkers of variable lengths containing a 1,...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Journal of Enzyme Inhibition and Medicinal Chemistry
المؤلفون الرئيسيون: I. Caroline Vaaland, Óscar López, Adrián Puerta, Miguel X. Fernandes, José M. Padrón, José G. Fernández-Bolaños, Magne O. Sydnes, Emil Lindbäck
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Taylor & Francis Group 2023-12-01
الموضوعات:
Cholinesterases
inhibitors
enantiomers
modelling
Alzheimer’s disease
الوصول للمادة أونلاين:https://www.tandfonline.com/doi/10.1080/14756366.2022.2150762

الانترنت

https://www.tandfonline.com/doi/10.1080/14756366.2022.2150762

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