An Integrated Strategy Based on 10-DAB Extraction and In Situ Whole-Cell Biotransformation of Renewable <i>Taxus</i> Needles to Produce Baccatin III

Baccatin III is a crucial precursor in the biosynthesis pathway of paclitaxel. Its main sources are extraction from <i>Taxus</i> or chemical synthesis using 10-deacetylbaccatin III (10-DAB) as substrate. However, these preparation approaches exhibit serious limitations, including the low...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Ping Kou, Yingying Yu, He Wang, Yuchi Zhang, Zhaoxia Jin, Fang Yu
Format:	Article
Language:	English
Published:	MDPI AG 2024-05-01
Subjects:	baccatin Ⅲ whole-cell biotransformation <i>Taxus</i> needles 10-deacetylbaccatin III-10-β-O-acetyltransferase acetyl-CoA supply
Online Access:	https://www.mdpi.com/1420-3049/29/11/2586