LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes

Abstract The Interleukin-36 (IL-36) cytokine family have emerged as important players in mounting an inflammatory response at epithelial barriers and tailoring appropriate adaptive immune responses. As members of the Interleukin-1 superfamily, IL-36 cytokines lack a signal peptide for conventional s...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Jennifer Keller, Judit Danis, Isabella Krehl, Eleftheria Girousi, Takashi K. Satoh, Barbara Meier-Schiesser, Lajos Kemény, Márta Széll, W. Wei-Lynn Wong, Steve Pascolo, Lars E. French, Thomas M. Kündig, Mark Mellett
Format:	Article
Language:	English
Published:	Nature Publishing Group 2025-03-01
Online Access:	https://doi.org/10.1038/s41419-025-07537-9