A Polymorphism in the Gene Encoding Heat Shock Factor 1 (<i>HSF1</i>) Increases the Risk of Type 2 Diabetes: A Pilot Study Supports a Role for Impaired Protein Folding in Disease Pathogenesis

The aim of this pilot study was to investigate whether polymorphisms in the gene encoding heat shock factor 1 (<i>HSF1</i>), a transcriptional activator of molecular chaperones, play a role in the development of type 2 diabetes (T2D). A total of 3229 unrelated individuals of Slavic origi...

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Bibliographic Details

Published in:	Life
Main Authors:	Elena Klyosova, Iuliia Azarova, Alexey Polonikov
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Subjects:	type 2 diabetes mellitus genetic susceptibility molecular chaperons heat shock factor 1 (HSF1) single nucleotide polymorphism gene expression
Online Access:	https://www.mdpi.com/2075-1729/12/11/1936