Patients with anti-SAE+ dermatomyositis display refractory and difficult-to-treat skin manifestations: case series from two Italian cohorts and review of literature

AimWe aimed to describe the clinical and serological characteristics of anti-small ubiquitin-like modifier-activating enzyme (SAE)-positive cases from a multicentric cohort of patients affected with idiopathic inflammatory myopathies (IIMs).MethodsAnti-SAE antibody-positive patients (determined by l...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Roberto Depascale, Anna Ghirardello, Elisabetta Zanatta, Chiara Franco, Marisol Bracalenti, Federico Pettorossi, Mariele Gatto, Elena Treppo, Beatrice Moccaldi, Margherita Zen, Stefano Piaserico, Christian Ciolfi, Luca Quartuccio, Andrea Doria, Luca Iaccarino
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	inflammatory myopathies dermatomyositis anti-SAE antibodies refractory skin involvement immunosuppresants
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1597282/full