The ubiquitination landscape of the influenza A virus polymerase

Influenza A virus replication relies on host cell-derived ubiquitination of the viral polymerase. Here, Günl et al. show that site-specific ubiquitination of PB1-K578 is acquired during infection and facilitates spatiotemporal control of polymerase dimerization and NP binding.

Bibliographic Details
Published in:Nature Communications
Main Authors: Franziska Günl, Tim Krischuns, Julian A. Schreiber, Lea Henschel, Marius Wahrenburg, Hannes C. A. Drexler, Sebastian A. Leidel, Vlad Cojocaru, Guiscard Seebohm, Alexander Mellmann, Martin Schwemmle, Stephan Ludwig, Linda Brunotte
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Online Access:https://doi.org/10.1038/s41467-023-36389-0

Internet

https://doi.org/10.1038/s41467-023-36389-0

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