Case Report: Successful treatment of a novel variant of CARD14-mutated juvenile Pityriasis rubra pilaris with ixekizumab

Pityriasis rubra pilaris is a rare inflammatory papulosquamous skin disease without any approved treatment options. Variants in the CARD14 (caspase recruitment domain family member 14) gene have been identified to play a role in the pathophysiology of atypical juvenile PRP by activating the IL-23/IL...

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Bibliographic Details

Published in:	Frontiers in Medicine
Main Authors:	Laura Millak, Matthias Hahn, Judith Fischer, Sebastian Volc
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	Pityriasis rubra pilaris case report ixekizumab CARD14 pediatric dermatology
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2025.1637045/full