Chrysophanol promotes M2 polarization and inhibits M1 polarization through the NF-κB signaling pathway to attenuate sepsis-associated acute kidney injury

ObjectiveSepsis-associated acute kidney injury (SA-AKI) is a frequent and severe complication in septic patients. This study combines network pharmacology with in vitro and in vivo experiments to preliminarily investigate the protective effect of chrysophanol (CHR) on SA-AKI and its mechanism, aimin...

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出版年:	Frontiers in Pharmacology
主要な著者:	Xuan Gou, Wei Zhang, Lele Wang, Caixia Tan, Hong Wei, Xinmin Wang, Le Zhang
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2025-07-01
主題:	chrysophanol sepsis acute kidney injury macrophage polarization inflammation
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1641068/full