CCDC137/DGCR8 axis promotes aerobic glycolysis in hepatocellular carcinoma via activation of the AKT/mTOR signaling pathway

Abstract Introduction Hepatocellular carcinoma (HCC) is a leading cause of global cancer fatality. Understanding its molecular mechanisms is crucial for developing effective treatments. Methods Differentially expressed genes (DEGs) in the cancer genome atlas (TCGA)–liver hepatocellular carcinoma (LI...

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Bibliographic Details
Published in:European Journal of Medical Research
Main Authors: Zhiying Xu, Wei Shi, Jialun Ren, Qifei Zou, Mingming Fan, Yiran Li, Dong Jiang
Format: Article
Language:English
Published: BMC 2025-09-01
Subjects:
Hepatocellular carcinoma
CCDC137
DGCR8
AKT/mTOR signaling pathway
Aerobic glycolysis
Online Access:https://doi.org/10.1186/s40001-025-03047-8

Internet

https://doi.org/10.1186/s40001-025-03047-8

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