Sodium hyaluronate supplemented culture medium combined with joint-simulating mechanical loading improves chondrogenic differentiation of human mesenchymal stem cells

In vitro models aim to recapitulate the in vivo situation. To more closely mimic the knee joint environment, current in vitro models need improvements to reflect the complexity of the native tissue. High molecular weight hyaluronan (hMwt HA) is one of the most abundant bioactive macromolecules in he...

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Bibliographic Details

Published in:	European Cells & Materials
Main Authors:	G Monaco, AJ El Haj, M Alini, MJ Stoddart
Format:	Article
Language:	English
Published:	Forum Multimedia Publishing LLC 2021-06-01
Subjects:	hyaluronic acid mesenchymal stem cells chondrogenic differentiation articular cartilage hypertrophy joint simulating bioreactor mechanical loading in vitro model culture medium tgf-β1
Online Access:	https://www.ecmjournal.org/papers/vol041/pdf/v041a40.pdf