Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates Toxoplasma dissemination

ABSTRACT Mononuclear phagocytes facilitate the dissemination of the obligate intracellular parasite Toxoplasma gondii. Here, we report how a set of secreted parasite effector proteins from dense granule organelles (GRA) orchestrates dendritic cell-like chemotactic and pro-inflammatory activation of...

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書誌詳細

出版年:	mBio
主要な著者:	Arne L. ten Hoeve, Matias E. Rodriguez, Martin Säflund, Valentine Michel, Lucas Magimel, Albert Ripoll, Tianxiong Yu, Mohamed-Ali Hakimi, Jeroen P. J. Saeij, Deniz M. Ozata, Antonio Barragan
フォーマット:	論文
言語:	英語
出版事項:	American Society for Microbiology 2024-10-01
主題:	mononuclear phagocyte intracellular parasitism host-pathogen cell signaling pathway immune cell migration
オンライン･アクセス:	https://journals.asm.org/doi/10.1128/mbio.02140-24