Predicting reverse-bound peptide conformations in MHC Class II with PANDORA

Recent discoveries have transformed our understanding of peptide binding in Major Histocompatibility Complex (MHC) molecules, showing that peptides, for some MHC class II alleles, can bind in a reverse orientation (C-terminus to N-terminus) and can still effectively activate CD4+ T cells. These find...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Daniel T. Rademaker, Farzaneh M. Parizi, Marieke van Vreeswijk, Sanna Eerden, Dario F. Marzella, Li C. Xue
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	reverse-bound peptides HLA II homology modeling peptide-MHC MHC II
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1525576/full