Cross-reactivity influences changes in human influenza A virus and Epstein Barr virus specific CD8 memory T cell receptor alpha and beta repertoires between young and old

Older people have difficulty controlling infection with common viruses such as influenza A virus (IAV), RNA virus which causes recurrent infections due to a high rate of genetic mutation, and Epstein Barr virus (EBV), DNA virus which persists in B cells for life in the 95% of people that become acut...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Fransenio Clark, Anna Gil, Ishwor Thapa, Nuray Aslan, Dario Ghersi, Liisa K. Selin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Subjects:	influenza A virus (IAV)-M158-66 epitope Epstein Barr virus (EBV)-BMLF1280-288 epitope Epstein Barr virus (EBV)-BRLF1109-117 epitope T cell receptor (TCR) repertoire crossreactivity aging
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1011935/full