A longitudinal study of the 5xFAD mouse retina delineates Amyloid beta (Aβ)-mediated retinal pathology from age-related changes

Abstract Background Age-related macular degeneration (AMD) is the commonest cause of irreversible blindness in developed societies. AMD coincides with advanced age to which genetic and lifestyle factors contribute additional risks. High levels of the Alzheimer’s-linked Amyloid beta (Aβ) proteins are...

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Bibliographic Details

Published in:	Alzheimer’s Research & Therapy
Main Authors:	Savannah A. Lynn, Sudha Priya Soundara Pandi, Aida Sanchez-Bretano, Anna-Marie Muir, Lidia Parker, David S. Chatelet, Tutte Newall, Jennifer A. Scott, Eloise Keeling, Neil R. Smyth, Jay E. Self, Andrew J. Lotery, Helena Lee, J. Arjuna Ratnayaka
Format:	Article
Language:	English
Published:	BMC 2025-06-01
Subjects:	5xFAD Retina Mouse model Amyloid beta (Aβ) Age Retinopathy
Online Access:	https://doi.org/10.1186/s13195-025-01784-w