Implications of practice effects for the design of Alzheimer clinical trials

Abstract INTRODUCTION Practice effects (PEs) are a well‐known potential confound in natural history studies of longitudinal cognitive decline in aging and early‐stage Alzheimer's disease. The implication of PEs on Alzheimer's disease clinical trials is less well understood, although we hav...

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Bibliographic Details

Published in:	Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Main Authors:	Jasmin A. Duehring, Diane M. Jacobs, Michael L. Thomas, Hiroko H. Dodge, Howard H. Feldman, Steven D. Edland
Format:	Article
Language:	English
Published:	Wiley 2025-07-01
Subjects:	clinical trial design clinical trial efficiency composite measures optimal weights practice effects
Online Access:	https://doi.org/10.1002/trc2.70154