Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine

Abstract TP53 nonsense mutations in cancer produce truncated inactive p53 protein. We show that 5-FU metabolite 5-Fluorouridine (FUr) induces full-length p53 in human tumor cells carrying R213X nonsense mutant TP53. Ribosome profiling visualized translational readthrough at the R213X premature stop...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Mireia Palomar-Siles, Angelos Heldin, Meiqiongzi Zhang, Charlotte Strandgren, Viktor Yurevych, Jip T. van Dinter, Sem A. G. Engels, Damon A. Hofman, Susanne Öhlin, Birthe Meineke, Vladimir J. N. Bykov, Sebastiaan van Heesch, Klas G. Wiman
Format:	Article
Language:	English
Published:	Nature Publishing Group 2022-11-01
Online Access:	https://doi.org/10.1038/s41419-022-05431-2