<i>IDH</i> Mutations in Glioma: Double-Edged Sword in Clinical Applications?

Discovery of point mutations in the genes encoding isocitrate dehydrogenases (IDH) in gliomas about a decade ago has challenged our view of the role of metabolism in tumor progression and provided a new stratification strategy for malignant gliomas. IDH enzymes catalyze the conversion of isocitrate...

Full description

Bibliographic Details

Published in:	Biomedicines
Main Authors:	Alisan Kayabolen, Ebru Yilmaz, Tugba Bagci-Onder
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Subjects:	isocitrate dehydrogenase (IDH) mutations glioma glioblastoma therapeutics clinical trials
Online Access:	https://www.mdpi.com/2227-9059/9/7/799