Challenges of aortic valve tissue culture – maintenance of viability and extracellular matrix in the pulsatile dynamic microphysiological system

Abstract Background Calcific aortic valve disease (CAVD) causes an increasing health burden in the 21st century due to aging population. The complex pathophysiology remains to be understood to develop novel prevention and treatment strategies. Microphysiological systems (MPSs), also known as organ-o...

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Bibliographic Details

Published in:	Journal of Biological Engineering
Main Authors:	Claudia Dittfeld, Maximilian Winkelkotte, Anna Scheer, Emmely Voigt, Florian Schmieder, Stephan Behrens, Anett Jannasch, Klaus Matschke, Frank Sonntag, Sems-Malte Tugtekin
Format:	Article
Language:	English
Published:	BMC 2023-09-01
Subjects:	Calcific aortic valve disease Tissue culture Microphysiological system Viability ECM remodelling
Online Access:	https://doi.org/10.1186/s13036-023-00377-1