Rotenone inhibited osteosarcoma metastasis by modulating ZO-2 expression and location via the ROS/Ca2+/AMPK pathway

Background Pulmonary metastases in osteosarcoma (OS) are associated with a poor prognosis. Rotenone has shown anti-cancer activity. However, its effects on metastasis and the underlying mechanisms remain unknown. This study investigated the potential use of Rotenone for OS treatment.Methods The effe...

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Bibliographic Details

Published in:	Redox Report
Main Authors:	Xiang Ma, Zhen Li, Hengwei Ma, Kun Jiang, Bao Chen, Weiquan Wang, Ziqiang Zhu, Jianqiang Wang, Zuozhang Yang, Wang Yunqing, Suwei Dong
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	Rotenone AMPK ZO-2 ROS Ca2+‌ metastasis
Online Access:	https://www.tandfonline.com/doi/10.1080/13510002.2025.2493556