Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia

Abstract Background Mixed lineage leukemia (MLL) gene translocations are found in ~75 % infant and 10 % adult acute leukemia, showing a poor prognosis. Lysine-specific demethylase 1 (LSD1) has recently been implicated to be a drug target for this subtype of leukemia. More studies using potent LSD1 i...

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Bibliographic Details

Published in:	Journal of Hematology & Oncology
Main Authors:	Zizhen Feng, Yuan Yao, Chao Zhou, Fengju Chen, Fangrui Wu, Liping Wei, Wei Liu, Shuo Dong, Michele Redell, Qianxing Mo, Yongcheng Song
Format:	Article
Language:	English
Published:	BMC 2016-03-01
Subjects:	MLL-rearranged leukemia Lysine-specific demethylase 1 Enzyme inhibitor Drug discovery Leukemia therapeutics
Online Access:	http://link.springer.com/article/10.1186/s13045-016-0252-7