Optogenetic Tuning Reveals Rho Amplification-Dependent Dynamics of a Cell Contraction Signal Network

Summary: Local cell contraction pulses play important roles in tissue and cell morphogenesis. Here, we improve a chemo-optogenetic approach and apply it to investigate the signal network that generates these pulses. We use these measurements to derive and parameterize a system of ordinary differenti...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Dominic Kamps, Johannes Koch, Victor O. Juma, Eduard Campillo-Funollet, Melanie Graessl, Soumya Banerjee, Tomáš Mazel, Xi Chen, Yao-Wen Wu, Stephanie Portet, Anotida Madzvamuse, Perihan Nalbant, Leif Dehmelt
Format:	Article
Language:	English
Published:	Elsevier 2020-12-01
Subjects:	rho GTPase cytoskeleton mechanotransduction myosin cell contraction optogenetics
Online Access:	http://www.sciencedirect.com/science/article/pii/S221112472031456X