Prediction of outcomes following intravenous thrombolysis in patients with acute ischemic stroke using serum UCH-L1, S100β, and NSE: a multicenter prospective cohort study employing machine learning methods

Background: Acute ischemic stroke (AIS) is a leading cause of mortality and disability worldwide. Intravenous thrombolysis (IVT) improves recovery, but predicting outcomes remains challenging. Machine learning (ML) and biomarkers like ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), S100 calcium-b...

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Bibliographic Details

Published in:	Therapeutic Advances in Neurological Disorders
Main Authors:	Ming-Ya Luo, Yang Qu, Peng Zhang, Reziya Abuduxukuer, Li-Juan Wang, Li-Chong Yang, Zhi-Guo Li, Xiao-Dong Liu, Ce Han, Dan Li, Wei-Jia Wang, Dian-Ping Lv, Ming Liu, Jian Gao, Jing Xu, Yongfei Jiang, Hai-Nan Chen, Fu-Jin Li, Li-Ming Sun, Qi-Dong Sun, Yingbin Qi, Si-Yin Sun, Yu Zhang, Zhen-Ni Guo, Yi Yang
Format:	Article
Language:	English
Published:	SAGE Publishing 2025-06-01
Online Access:	https://doi.org/10.1177/17562864251342429