Transhydrogenase promotes the robustness and evolvability of E. coli deficient in NADPH production.

Metabolic networks revolve around few metabolites recognized by diverse enzymes and involved in myriad reactions. Though hub metabolites are considered as stepping stones to facilitate the evolutionary expansion of biochemical pathways, changes in their production or consumption often impair cellula...

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Bibliographic Details

Published in:	PLoS Genetics
Main Authors:	Hsin-Hung Chou, Christopher J Marx, Uwe Sauer
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Online Access:	https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005007&type=printable