Pharmacological and non-pharmacological modulation of endoplasmic reticulum stress in pediatric diabetes

In all forms of pediatric diabetes, the endoplasmic reticulum (ER) stress acquires a significant role, as a factor that contributes to the dysfunction and apoptosis of the pancreatic β- cells. The integrity of the ER response is critical as a molecular mechanism for alleviating stress during insulin...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Author:	Aristeidis P. Giannakopoulos
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	pediatric diabetes endoplasmic reticulum stress unfolded protein response exercise metformin
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2025.1690478/full