Hyaluronic Acid Prevents Fusion of Brain Tumor-Derived Spheroids and Selectively Alters Their Gene Expression Profile

Hyaluronic acid (HA), a major glycosaminoglycan of the brain extracellular matrix, modulates cell behaviors through binding its receptor, Cd44. In this study, we assessed the influence of HA on high-grade brain tumors in vitro. The model comprised cell cultures derived from six rodent carcinogen-ind...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Irina Arutyunyan, Anna Soboleva, Dorzhu Balchir, Enar Jumaniyazova, Vera Kudelkina, Andrey Elchaninov, Timur Fatkhudinov
Format:	Article
Language:	English
Published:	MDPI AG 2024-04-01
Subjects:	high-grade brain tumors tissue strains 3D culture spheroids hyaluronic acid spheroid fusion
Online Access:	https://www.mdpi.com/2218-273X/14/4/466