Next-Gen GWAS: full 2D epistatic interaction maps retrieve part of missing heritability and improve phenotypic prediction

Abstract The problem of missing heritability requires the consideration of genetic interactions among different loci, called epistasis. Current GWAS statistical models require years to assess the entire combinatorial epistatic space for a single phenotype. We propose Next-Gen GWAS (NGG) that evaluat...

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出版年:	Genome Biology
主要な著者:	Clément Carré, Jean Baptiste Carluer, Christian Chaux, Chad Estoup-Streiff, Nicolas Roche, Eric Hosy, André Mas, Gabriel Krouk
フォーマット:	論文
言語:	英語
出版事項:	BMC 2024-03-01
オンライン･アクセス:	https://doi.org/10.1186/s13059-024-03202-0