A gp41 HR2 residue modulates the susceptibility of HIV-1 envelope glycoproteins to small molecule inhibitors targeting gp120

ABSTRACT One characteristic of the HIV-1 CRF01_AE strain is that it contains a bulkier histidine residue at position 375 (H375) in its envelope glycoproteins (Env). This residue is part of the Phe43 cavity, where residue 43 of CD4 engages with gp120. It has been shown that H375 contributes to resist...

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Bibliographic Details

Published in:	Journal of Virology
Main Authors:	Debashree Chatterjee, Ling Niu, Halima Medjahed, Shilei Ding, Mehdi Benlarbi, Étienne Bélanger, Jérémie Prévost, Hung-Ching Chen, William D. Tolbert, Amos B. Smith, Marzena Pazgier, Andrés Finzi
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-04-01
Subjects:	HIV Env gp120 gp41 CRF01_AE temsavir
Online Access:	https://journals.asm.org/doi/10.1128/jvi.02267-24