CD91-mediated reprogramming of DCs by immunogenic heat shock proteins requires the kinases AXL and Fgr

Abstract Immune responses to tumors, comprising adaptive T cells and innate NK cells, arise very early in tumorigeneses and prior to detection of palpable tumors or before tissue pathology is evident. Yet, how nascent tumors evoke dendritic cell maturation and the resulting cytokine responses that a...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	James Trey F. Harkness, Devanshi A. Nayak, Abigail L. Sedlacek, Richard Cattley, William F. Hawse, Simon C. Watkins, Robert J. Binder
Format:	Article
Language:	English
Published:	BMC 2024-12-01
Subjects:	CD91/LRP1 Heat shock proteins Dendritic cells Cancer immunosurveillance AXL Fgr
Online Access:	https://doi.org/10.1186/s12964-024-01901-6