PERK-Mediated Suppression of microRNAs by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure

Summary: Oxidative/nitrosative stress is a major trigger of cardiac dysfunction, involving the unfolded protein response and mitochondrial dysfunction. Activation of nitric oxide-cyclic guanosine monophosphate-protein kinase G signaling by sildenafil improves cardiac mal-remodeling during pressure-o...

Full description

Bibliographic Details

Published in:	iScience
Main Authors:	Takashi Shimizu, Akashi Taguchi, Yoshiki Higashijima, Naoko Takubo, Yasuharu Kanki, Yoshihiro Urade, Youichiro Wada
Format:	Article
Language:	English
Published:	Elsevier 2020-08-01
Subjects:	Biological Sciences Molecular Biology Cell Biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004220306003