An immunomodulatory photosensitizer-mediated photodynamic therapy synergizes with PD-L1 blockade against metastatic triple-negative breast cancer

The clinical potency of anti-programmed death-ligand 1 (PD-L1) therapy in metastatic triple-negative breast cancer (TNBC) is modest primarily because of the intrinsic low immunogenicity and an immunosuppressive tumor microenvironment (TME). Photodynamic therapy (PDT), an inducer of immunogenic cell...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Yuetong Liu, Liming Wang, Feiyan Kong, Tianjun Liu, Hong Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	photodynamic therapy immunogenic cell death metastatic triple-negative breast cancer programmed death-ligand 1 blockade abscopal effect systemic antitumor immunity
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1651165/full