Labeling of DOTA-conjugated HPMA-based polymers with trivalent metallic radionuclides for molecular imaging

Abstract Background In this work, the in vitro and in vivo stabilities and the pharmacology of HPMA-made homopolymers were studied by means of radiometal-labeled derivatives. Aiming to identify the fewer amount and the optimal DOTA-linker structure that provides quantitative labeling yields, diverse...

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Bibliographic Details

Published in:	EJNMMI Research
Main Authors:	Elisabeth Eppard, Ana de la Fuente, Nicole Mohr, Mareli Allmeroth, Rudolf Zentel, Matthias Miederer, Stefanie Pektor, Frank Rösch
Format:	Article
Language:	English
Published:	SpringerOpen 2018-02-01
Subjects:	DOTA-HPMA conjugates Theranostic Radiolabeling Gallium-68 Scandium-44 Lutetium-177
Online Access:	http://link.springer.com/article/10.1186/s13550-018-0372-x