Repurposing nitrofurantoin as a stimulant of fibroblast extracellular matrix repair for the treatment of emphysema

Emphysema is a respiratory disease that causes the progressive loss of lung extracellular matrix (ECM) organisation, subsequently undermining lung integrity and reducing lung function. Fibroblasts must constantly repair damage to the lungs to preserve lung health, however, fibroblast ECM repair is r...

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Bibliographic Details

Published in:	Medicine in Drug Discovery
Main Authors:	Mathew N. Leslie, Zara Sheikh, Dikaia Xenaki, Brian G. Oliver, Paul M. Young, Daniela Traini, Hui Xin Ong
Format:	Article
Language:	English
Published:	Elsevier 2024-09-01
Subjects:	Emphysema Nitrofurantoin Fibroblast Extracellular matrix Pulmonary fibrosis Lung
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590098624000198