Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis

Abstract Orofacial cleft (OFC) is a common human congenital anomaly. Epithelial-specific RNA splicing regulators ESRP1 and ESRP2 regulate craniofacial morphogenesis and their disruption result in OFC in zebrafish, mouse and humans. Using esrp1/2 mutant zebrafish and murine Py2T cell line models, we...

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Bibliographic Details

Published in:	Communications Biology
Main Authors:	Caroline Caetano da Silva, Claudio Macias Trevino, Jason Mitchell, Hemma Murali, Casey Tsimbal, Eileen Dalessandro, Shannon H. Carroll, Simren Kochhar, Sarah W. Curtis, Ching Hsun Eric Cheng, Feng Wang, Eric Kutschera, Russ P. Carstens, Yi Xing, Kai Wang, Elizabeth J. Leslie, Eric C. Liao
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-08-01
Online Access:	https://doi.org/10.1038/s42003-024-06715-3