Severe Immune Checkpoint Inhibitor Hepatitis in KRAS G12C-Mutant NSCLC Potentially Triggered by Sotorasib: Case Report

Sotorasib is a first-in-class small molecule that irreversibly inhibits KRAS G12C, locking it in an inactive state, inhibiting oncogenic signaling, and inducing a proinflammatory microenvironment. Here, we report the first case of life-threatening hepatitis in a patient with NSCLC shortly after comm...

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Bibliographic Details

Published in:	JTO Clinical and Research Reports
Main Authors:	Parvin Begum, MBChB.(Hons), Robert D. Goldin, MD, Lucia A. Possamai, PhD, Sanjay Popat, FRCP, PhD
Format:	Article
Language:	English
Published:	Elsevier 2021-09-01
Subjects:	Sotorasib Autoimmune hepatitis Immune checkpoint inhibitor KRAS G12C Case report
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666364321000722