The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry

MKLP2, a kinesin-6, has critical roles during the metaphase-anaphase transition and cytokinesis. Its motor domain contains conserved nucleotide binding motifs, but is divergent in sequence (~35% identity) and size (~40% larger) compared to other kinesins. Using cryo-electron microscopy and biophysic...

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Bibliographic Details
Published in:eLife
Main Authors: Joseph Atherton, I-Mei Yu, Alexander Cook, Joseph M Muretta, Agnel Joseph, Jennifer Major, Yannick Sourigues, Jeffrey Clause, Maya Topf, Steven S Rosenfeld, Anne Houdusse, Carolyn A Moores
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Subjects:
cryo-electron microscopy
kinesins
mechanochemistry
microtubules
mitosis
ATPase
Online Access:https://elifesciences.org/articles/27793

Internet

https://elifesciences.org/articles/27793

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