Rutin ameliorates stress–induced blood‒brain barrier dysfunction and cognitive decline via the endothelial HDAC1‒Claudin–5 axis

Abstract Background Emerging evidence suggests that chronic stress compromises blood‒brain barrier (BBB) integrity by disrupting brain microvascular endothelial cells (BMECs), contributing to the development of cognitive impairments. Thus, targeting the BBB is expected to be a promising treatment st...

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Bibliographic Details

Published in:	Fluids and Barriers of the CNS
Main Authors:	Zhao–Wei Sun, Zhao–Xin Sun, Yun Zhao, Ling Zhang, Fang Xie, Xue Wang, Jin–Shan Li, Mao–Yang Zhou, Hong Feng, Ling–Jia Qian
Format:	Article
Language:	English
Published:	BMC 2025-04-01
Subjects:	Rutin Stress–induced cognitive decline BBB BMEC function Claudin–5 H3K27ac modification
Online Access:	https://doi.org/10.1186/s12987-025-00639-8