ASF1A-dependent P300-mediated histone H3 lysine 18 lactylation promotes atherosclerosis by regulating EndMT

Endothelial-to-mesenchymal transition (EndMT) is a key driver of atherosclerosis. Aerobic glycolysis is increased in the endothelium of atheroprone areas, accompanied by elevated lactate levels. Histone lactylation, mediated by lactate, can regulate gene expression and participate in disease regulat...

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Bibliographic Details

Published in:	Acta Pharmaceutica Sinica B
Main Authors:	Mengdie Dong, Yunjia Zhang, Minghong Chen, Yongkang Tan, Jiao Min, Xian He, Fuhao Liu, Jiaming Gu, Hong Jiang, Longbin Zheng, Jiajing Chen, Quanwen Yin, Xuesong Li, Xiang Chen, Yongfeng Shao, Yong Ji, Hongshan Chen
Format:	Article
Language:	English
Published:	Elsevier 2024-07-01
Subjects:	Histone lactylation Atherosclerosis Endothelial-to-mesenchymal transition ASF1A SNAI1 Endothelial dysfunction
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383524000893