20(S)-protopanaxadiol prolongs lifespan and enhances stress resistance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway

IntroductionAging is a progressive and irreversible process linked to a variety of diseases. Examination of the processes targeted by pharmacological treatments could potentially both extend lifespan and alleviate age-associated diseases. 20(S)-protopanaxadiol (20(S)-PPD), a primary ginsenoside meta...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Zhuo Song, Xiuci Yan, Xiaohao Xu, Tingting Lou, Yu Wang, Limei Ren, Fangbing Liu, Shuai Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	Caenorhabditis elegans 20(S)-protopanaxadiol longevity insulin/IGF-1 signaling pathway DAF-16/FOXO
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1657436/full