The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration

The sigma-1 receptor (Sig-1R) is a single 25 kD polypeptide and a chaperone protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with mitochondria at the mitochondria-associated ER membrane domain (MAM). Upon activation, the Sig-1R binds to the inositol trisphosphate...

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Bibliographic Details

Published in:	Journal of Pharmacological Sciences
Main Authors:	Karsten Ruscher, Tadeusz Wieloch
Format:	Article
Language:	English
Published:	Elsevier 2015-01-01
Subjects:	Lipid raft Neuroprotection Neurorestoration Sigma-1 receptor Stroke
Online Access:	http://www.sciencedirect.com/science/article/pii/S134786131400019X