PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice

Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease characterized by the excessive accumulation of activated myofibroblasts that deposit extracellular matrix (ECM) protein, leading to progressive scar formation and mechanical stress. However, the cellular origin and fate o...

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Bibliographic Details

Published in:	The Journal of Clinical Investigation
Main Authors:	Liran Xu, Ting Li, Yapeng Cao, Yu He, Zehua Shao, Siyu Liu, Bianbian Wang, Ailing Su, Huijing Tian, Yongxin Li, Guozheng Liang, Changhe Wang, John Shyy, Ying Xiong, Fangyuan Chen, Jason X.J. Yuan, Junjun Liu, Bin Zhou, Nina Wettschureck, Stefan Offermanns, Yang Yan, Zuyi Yuan, Shengpeng Wang
Format:	Article
Language:	English
Published:	American Society for Clinical Investigation 2025-06-01
Subjects:	Cell biology Pulmonology
Online Access:	https://doi.org/10.1172/JCI184158