Effects of the Calix[4]arene Derivative Compound OTX008 on High Glucose-Stimulated ARPE-19 Cells: Focus on Galectin-1/TGF-β/EMT Pathway

Diabetic retinopathy (DR) is a neurovascular disease characterized by the reduction of retina integrity and functionality, as a consequence of retinal pigment epithelial cell fibrosis. Although galectin-1 (a glycan-binding protein) has been associated with dysregulated retinal angiogenesis, no evide...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Maria Consiglia Trotta, Francesco Petrillo, Carlo Gesualdo, Settimio Rossi, Alberto Della Corte, Judit Váradi, Ferenc Fenyvesi, Michele D’Amico, Anca Hermenean
Format:	Article
Language:	English
Published:	MDPI AG 2022-07-01
Subjects:	diabetic retinopathy retinal pigment epithelial cells galectin-1 OTX008 fibrosis epithelial-mesenchymal transition
Online Access:	https://www.mdpi.com/1420-3049/27/15/4785