Targeting ESR1 mutation–induced transcriptional addiction in breast cancer with BET inhibition

Acquired mutations in the ligand-binding domain (LBD) of the gene encoding estrogen receptor α (ESR1) are common mechanisms of endocrine therapy resistance in patients with metastatic ER+ breast cancer. The ESR1 Y537S mutation, in particular, is associated with development of resistance to most endo...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	JCI Insight
المؤلفون الرئيسيون:	Sm N. Udden, Qian Wang, Sunil Kumar, Venkat S. Malladi, Shwu-Yuan Wu, Shuguang Wei, Bruce A. Posner, Sophie Geboers, Noelle S. Williams, Yulun Liu, Jayesh K. Sharma, Ram S. Mani, Srinivas Malladi, Karla Parra, Mia Hofstad, Ganesh V. Raj, Jose M. Larios, Reshma Jagsi, Max S. Wicha, Ben Ho Park, Gaorav P. Gupta, Arul M. Chinnaiyan, Cheng-Ming Chiang, Prasanna G. Alluri
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	American Society for Clinical investigation 2022-09-01
الموضوعات:	Oncology
الوصول للمادة أونلاين:	https://doi.org/10.1172/jci.insight.151851