AlphaFold2 assists in providing novel mechanistic insights into the interactions among the LUBAC subunits

The linear ubiquitin chain assembly complex (LUBAC) is the only known E3 ligase complex in which the ubiquitin-like (UBL) domains of SHARPIN and HOIL-1L interact with HOIP to determine the structural stability of LUBAC. The interactions between subunits within LUBAC have been a topic of extensive re...

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Bibliographic Details

Published in:	Acta Biochimica et Biophysica Sinica
Main Authors:	Wang Chenchen, Gu Chunying, Lv Ying, Liu Hongyu, Wang Yanan, Zuo Yongmei, Jiang Guangyu, Liu Lili, Liu Jiafu
Format:	Article
Language:	English
Published:	China Science Publishing & Media Ltd. 2024-04-01
Subjects:	LUBAC LTM motif HOIP-UBA HOIL-1L-UBL SHARPIN-UBL
Online Access:	https://www.sciengine.com/doi/10.3724/abbs.2024047