Gasdermin D is activated but does not drive neurodegeneration in SOD1G93A model of ALS: Implications for targeting pyroptosis

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss, microgliosis, and neuroinflammation. While pyroptosis, an inflammatory form of programmed cell death, has been implicated in ALS, the specific role of Gasdermin D (GSDMD) - the pr...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Georgia Gunner, Himanish Basu, Yueting Lu, Matthew Bergstresser, Liwei Sun, Dylan Neel, So Yoen Choi, Isaac M. Chiu
Format:	Article
Language:	English
Published:	Elsevier 2025-10-01
Subjects:	ALS Microglia Pyroptosis Gasdermin D Neuroimmunology Cell death
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996125002645