The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene

The epitranscriptomic writer Alkylation Repair Homolog 8 (ALKBH8) is a transfer RNA (tRNA) methyltransferase that modifies the wobble uridine of selenocysteine tRNA to promote the specialized translation of selenoproteins. Using Alkbh8 deficient (Alkbh8def) mice, we have investigated the importance...

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Bibliographic Details

Published in:	Epigenetics
Main Authors:	Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, Lauren Endres, Sara Evke, Steven Nevins, Samuel Martin, Peter C. Dedon, J. Andres Melendez, Laura Van Winkle, Qing-Yu Zhang, Xinxin Ding, Thomas J. Begley
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2020-10-01
Subjects:	epitranscriptomics rna modification tolerance naphthalene alkbh8 selenoprotein translation stress response
Online Access:	http://dx.doi.org/10.1080/15592294.2020.1750213