Covalent Inhibition of the <i>Human</i> 20S Proteasome with Homobelactosin C Inquired by QM/MM Studies

20S proteasome is a main player in the protein degradation pathway in the cytosol, thus intervening in multiple pivotal cellular processes. Over the years the proteasome has emerged as a crucial target for the treatment of many diseases such as neurodegenerative diseases, cancer, autoimmune diseases...

Full description

Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Natalia Serrano-Aparicio, Silvia Ferrer, Katarzyna Świderek
Format:	Article
Language:	English
Published:	MDPI AG 2022-04-01
Subjects:	20S proteasome covalent inhibition β-lactone homobelactosin C QM/MM molecular dynamic
Online Access:	https://www.mdpi.com/1424-8247/15/5/531